Metformin in Tuberous Sclerosis Complex - MiTS

This is a randomized double-blind placebo-controlled trial of metformin in tuberous sclerosis complex (TSC).  In this trial we are investigating the effect of the drug metformin on size of kidney tumours in patients with TSC.  We are also examining the effect of metformin on the size of brain tumours and facial tumours, epilepsy, cognitive abilities, and overall quality of life in these patients.

This trial is led by Dr Finbar O'Callaghan.

The National Institute for Health Research (NIHR) has funded this trial via a Research for Patient Benefit Grant.